Entry Laboratory Sciences Professional – Appel Research Lab

Job Summary:

A position as an Entry Laboratory Sciences Professional is available within the Appel research laboratory in the Department of Pediatrics, Section of Developmental Biology, at the University of Colorado Anschutz. This is a full-time (1.0FTE) position that will utilize molecular, biochemical, genetic, light microscopy, and zebrafish embryological approaches in a wet lab setting.

The Appel lab studies the formation of neurons and glial cells in the developing nervous system. As an Entry Laboratory Sciences Professional in our lab, you will work closely with graduate students and postdoctoral fellows to support their projects. The work is highly flexible and variable and includes standard molecular biology techniques (PCR, subcloning, gel electrophoresis, in situ RNA hybridization, immunohistochemistry), light microscopy (fluorescence and confocal microscopy), zebrafish husbandry, and zebrafish embryological experiments.

Key Responsibilities:

• Collaborate with and support Principal Investigators (PI) and other stakeholders with laboratory and research functions

• Utilize a variety of laboratory techniques required for research projects

• Perform experiments, tabulate, and analyze research

• Support analytical testing process using standard lab support knowledge in the collection and review of conditions, including preserving samples, completing sample preparation, documenting, and communicating results

• Perform pre-analytical, analytical, and post-analytical test processes and evaluate the results produced

• Prepare lab for daily operations, including stocking materials, equipment, safety, cleanliness, and related areas

• Provide animal care related to research studies, as necessary

• Pick up, transport, and maintain results, samples, documents, materials, and other items as needed

• Dispose of laboratory materials and samples using well-established guidelines and instructions

• Review, complete, and process logs, documents, databases, and related materials and information

• Provide support in researching issues and developing recommendations to resolve process, unit, and related issues

• Assist in the review and implementation of lab support policies, practices, and programs to meet organizational, operational and management needs

• Assist with ensuring compliance with applicable laws, rules, and regulations; receive guidance and direction or escalate when required

Additional Duties & Responsibilities:

• Genotype zebrafish embryos, larvae, and adults

• Perform molecular cloning, PCR, and gel electrophoresis

• Perform microinjections into zebrafish eggs for transgenesis and CRISPR/Cas9 experiments

• Perform in situ RNA hybridization and immunohistochemistry

• Analyze samples using confocal light microscopy

Work Location:

Why Join Us:

Onsite – this role is expected to work onsite and is located in Aurora, CO.

The Appel research group is part of a highly cohesive academic unit in the Section of Developmental Biology within the Department of Pediatrics. The Section of Developmental Biology is committed to research that improves child health with five main objectives:

• Understand the genetic, molecular, and cellular mechanisms that guide normal development

• Determine how normal developmental processes are altered to result in developmental disease and disability

• Identify new diagnostic strategies and molecular and cellular therapies targeted at the treatment of childhood disease

• Train the next generation of leaders in developmental and stem cell biology and pediatric disease research

• Serve as a hub for basic and translational child health research that spans the Anschutz Medical Campus research community

To accomplish these objectives, the faculty, graduate students, postdoctoral trainees, and research staff who comprise the Section of Developmental Biology perform research using stem cell, organoid, and animal experimental models, including Drosophila, zebrafish, and mice. Our investigations focus on several major tissue and organ systems, such as the brain, heart, intestine, face, vascular, olfactory, and immune systems. Our work is leading to a better understanding of childhood disabilities associated with neuropsychiatric disease, Down syndrome, the congenital basis of cardiovascular and facial malformations, and the impact of maternal health on fetal development.

Qualifications:

Minimum Qualifications:

• Bachelor’s degree in biology, molecular biology, chemistry, genetics, or related field

Applicants must meet minimum qualifications at the time of hire.

Preferred Qualifications:

• Master’s degree in biology, molecular biology, chemistry, genetics, or related field

• Prior experience or background within an experimental or wet lab

Knowledge, Skills, and Abilities:

• Knowledge of basic laboratory techniques, including safety procedures and techniques

• Ability to communicate effectively, both in writing and orally

• Ability to establish and maintain effective working relationships with employees at all levels throughout the institution

• Outstanding customer service skills

• Knowledge of basic human anatomy, physiology, and medical terminology

• Ability to interpret and master complex research protocol information

How to Apply:

For full consideration, please submit the following document(s):

1.   A letter of interest describing relevant job experiences as they relate to the listed job qualifications and interest in the position

2.   Curriculum vitae / Resume

3.   Three to five professional references, including name, address, phone number (mobile number if appropriate), and email address

Questions should be directed to\: Bruce Appel, bruce.appel@cuanschutz.edu

Screening of Applications Begins:

Immediately and continues until the position is filled. For best consideration, apply by December 15, 2025.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as

$46,274 to $58,861.

The above salary range (or hiring range) represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans, and retirement contributions that add to your bottom line.

Total Compensation Calculator\: http\://www.cu.edu/node/153125

Equal Employment Opportunity Statement:

The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing non-discrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply, including protected veterans and individuals with disabilities.

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@cuanschutz.edu​.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students, and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine-preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety-sensitive job duties, you must enroll in the occupational health medical surveillance program.